Current Research and Interests

1. The effects of biomechanical forces on the differentiation of mesenchymal stem cells (MSCs)

We are investigating the activation mechanism of mechanosensors upon mechanical stimuli and the mechanotransduction pathways involved in MSC differentiation.

2. Development of microfluidic biochips for MSC culturing

Microfluidic devices provide better control over the parameters of chemical gradients and mechanical stimuli. Culturing MSCs in lineage-specific biomechanical microenvironments using the devices could be beneficial for MSC differentiation.

3. Cancer immunotherapy

We are evaluating the selectivity of multifunctional nanoparticles (MNPs) to APCs and CTLA-4+ T cells, as well as the delivery efficiency of MNP-associated siRNA. The therapeutic efficacy of MNPs on melanoma will be assessed.